Amber Theoharis interviews Luke Scott about the Birds' 9-6 loss
But after Alex Rodriguez's single tied the game in the 6th, New York hit back-to-back homers in the 7th off Chris Ray to lead 9-6.
Nick Swisher's two-run homer made it 8-6 and Eric Hinske followed with a solo shot to left.
Robinson Cano had three hits, including a two-run homer and Jorge Posada homered twice for the Yankees - his 16th multi-homer game.
Melvin Mora had three hits for the O's, including a two-run single and Felix Pie hit a solo homer in the last of the first.
New York starter A.J. Burnett gave up six runs and 11 hits in 5 1/3 and O's starter David Hernandez allowed five runs in five frames.
The Yankees, who have won nine in a row vs. the Orioles, are 69-31 over their past 100 games.
The Yankees lead the Majors with 207 homers.
NYY.....9-12-1
Balt.....6-13-1