Yep, it happened again: O's lose in a walk-off

On the day Ryan Mountcastle hit his first two homers, both giving the Orioles the lead, would it be enough to end a four-game losing streak?

Mountcastle blasted No. 1 on a 2-2 changeup off Tanner Roark in the second. That gave the O's a 1-0 lead. He hit No. 2 off a Roark fastball with a man on in the sixth. That gave the O's a 4-3 lead.

But after Toronto tied it 4-4 in the last of the eighth, the O's had to take the lead again. And they did in the ninth on an infield RBI single up the middle by José Iglesias. It scored Rio Ruiz, who singled to right to lead off the ninth and was sacrificed to second base.

That lead would not hold, as Toronto won it with two outs in the last inning for the second time in three games. Teoscar Hernández's two-run single to left gave Toronto a 6-5 win in the ninth over the Orioles, who endured heartbreak again in Buffalo.

They fall to 14-19 and have lost five in a row and 11 of the last 13 games. They are 0-6 versus Toronto.

Toronto loaded the bases with two outs off Cole Sulser and the O's were a strike away as the count went to 1-2 on Hernández. But he singled between short and third and two runs scored to end the game.

It was a game with plenty of frustration for the Orioles, even before the ending.

Right-hander Jorge López retired the first nine batters on just 26 pitches. But he gave up a run on Vladimir Guerrero Jr.'s RBI single up the middle in the fourth to tie the game 1-1. It looked like shortstop Andrew Velazquez had a chance to make the play ranging up the middle, but it scooted by his glove as a run scored.

López needed just 41 pitches to get through four innings. But he would start the fifth by walking No. 7 hitter Lourdes Gurriel Jr. and No. 8 batter Joe Panik. Both would come around to score later on a single and a sac fly, and Toronto broke the tie to take a 3-1 lead.

A three-run O's sixth put the Orioles ahead 4-3, but they should have scored more in that inning. Still, they had the lead. All they had to do was hold it.

The sixth began with a Renato Núñez double to deep center and he scored on Pedro Severino's single to left. That hit pulled the Birds within 3-2 and gave Severino 17 RBIs his last 17 games. When Mountcastle followed with his second homer, the O's took the lead.

Mason Williams greeted reliever Anthony Kay with a triple to third. But he would get put out in a rundown between third and home when someone apparently missed a sign. Williams broke home but Velazquez, who had showed bunt, did not bunt. A chance for a two-run lead and bigger inning was missed.

According to STATS, four Orioles have had a multi-homer game within their first eight games. Mountcastle joined a list today that includes Manny Machado on Aug. 10, 2012 against Kansas City. Also Jim Fuller on Sept. 25, 1973 versus the Tigers and Curt Blefary on April 17, 1965 against the Red Sox.

But the kid's day was tarnished by the latest gut-punch loss for the team and they remain winless on this road trip.